Set in 1895, Bramwell follows the fortunes of Dr. Eleanor Bramwell in her pursuit of public health and private amours in Victorian-era London. Feisty and unconventional, her sights are set on becoming a leading surgeon, an ambition unheard of for women in Victorian society. The lavish period drama begins with Eleanor assisting at the East London Hospital of eminent surgeon Sir Herbert Hamilton. From the very beginning Eleanor's desire to take the medical profession out of the dark ages draws her into conflict with Sir Hamilton's old fashioned and often barbaric practices. But Eleanor's energy and compassion are recognized by Lady Cora Peters, who sets her up in a small charitable infirmary in the slums where Eleanor will encounter the difficulties and dangers of attending to the needs of London's poor and the criminal underworld that share London's East End.