As the Bartlet administration enters the last year, Oval Office hopefuls emerge from both major parties. And so do political strategists eager to back those bids for the White House--dreamers and doers willing to leave their West Wing posts for another grab at the brass ring. An up-and-coming congressman (Jimmy Smits) and an astute Republican senator (Alan Alda) are among the presidential aspirants. But in addition to running for office, there's the business of running the country--a job on the shoulders of Bartlet and his now reorganized staff. It's a taxing job under any circumstance, even more so when the nation's commander-in-chief battles the ravages of MS.